Purpura is a disease in which there is leakage of blood out of the blood vessels in the skin or mucosa, causing the presence of painless purplish spots, called petechiae small and large number stains or ecchymoses larger patches. It is a condition in, which there is bruising purpura because there are fewer platelets in the blood than usual thrombocytopenia and it is not known what causes it idiopathic. Purpura trombocitopenica autoinmune caso clinico y revision bibliografica luis angel sequeira rojas s u m m a r y the itp is a blood illness, characterize by thrombocytopenic, and it variability intense level. You may also hear the condition referred to as immune thrombocytopenia purpura which means it could have been caused. Thrombotic thrombocytopenic purpura ttp is the most extensive and dangerous intravascular platelet clumping disorder. Protocolo clinico e diretrizes terapeuticas purpura. Moschcowitz was the first to inform multiple hyaline thrombi as the primordial finding of a partial autopsy case. Thrombotic thrombocytopenic purpura, atypical hemolytic uremic syndrome. Immune thrombocytopenia purpura itp, also known as idiopathic thrombocytopenic purpura, is a type of thrombocytopenic purpura defined as an isolated low platelet count with a normal bone marrow in. Thrombocytopenic thrombotic purpura ttp is a severe hemorrhagic syndrome characterized by thrombocytopenia, microangiopathic hemolytic anemia and microvascular occlusion, besides the. Purpura trombotica trombocitopenica ptt the oncology. Purpura trombocitopenica aguda presentacion clinica y manejo en pacientes.
Thrombotic thrombocytopenic purpura ttp is a blood disorder that results in blood clots forming in small blood vessels throughout the body. Esta enfermedad afecta a varones y a mujeres por igual. Eperto e bases del diagstico e hematologa 4 purpura trombotica trombocitopenica y sindrome hemolitico uremico figura 1. Diatesis hemorragica, reaccion a farmacos, sepsis, malos tratos. Diopathic thrombocytopenic purpura itp, also known as primary immune thrombocytopenic purpura is a hematologic disorder for which appropriate diagnostic and treatment strategies are uncertain. The etiopathogenic mechanisms may result from abnormalities in any of the three components of hemostasis. Thrombotic thrombocytopenic purpura ttp is a particular form of tma.
Purpura trombocitopenica imuna, agerpres, 25 mar 2015 spitalul. Trombocitopenia inmunitaria primaria alvaradoibarra m 1, aguilarandrade c1, alvarezvera jl, amadorperez ao1, anayacuellar i2, anorvehernandez e3, baezislas pe1, batesmartin. For more than a halfcentury after its initial recognition, mortality was near 100%. Mar 30, 2016 purpura trombocitopenica inmune inmune julian criado clinica medica heep noviembre 2015 2. Purpura trombocitopenica autoinmune caso clinico y revision. Purpura results from the extravasation of blood cells into the skin andor mucous membranes giving rise to small purple coloured areas that do not disappear under pressure. Embolizacion parcial esplenica en purpura trombocitopenia.
Thrombotic thrombocytopenic purpura blood american. Some specialists advocate the use of 20,000 rather than 30,000 platelets per cubic millimeter as the thr eshold for therapy in p atients. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Thrombocytopenic purpura is mostly responsible for episodes of mucocutaneous bleeding.
It can produced in health people, but in children has been associated to viral infection, or bacterial infection. Purpura trombotica trombocitopenica y sindrome hemolitico uremico. Thrombotic thrombocitopenic purpura is a rare disease with a morphological expression featured of many microthrombi in the terminal arterioles of several vital structures. Today, two forms of severe enzymatic deficiency are. Adamts, purpura trombotica trombocitopenica, sindrome uremico hemolitico atipico. The incidence of thrombotic thrombocytopenic purpura. The last 20 years have been marked by the connection between an old disease, the thrombotic thrombocytopenic purpura ttp, 1 and a young protein, adamts a disintegrin and metalloprotease with thrombospondin type 1 repeats, member. In the majority of ttp patienst, metalloprotease adamts is severely deficient. This results in a low platelet count, low red blood cells due to. He proposed that a powerful poison with both agglutina.
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